Three simple, accurate and precise spectrophotometric methods have been developed for simultaneous estimation of Rosuvastatin calcium (ROSU) and Aspirin (ASP) from Capsule dosage form. Methanol: Phosphate buffer (80:20), 0.02M, pH 4.0, was used as solvent. First method, Simultaneous equation method, involves the measurement of absorbances at two wavelengths 242 nm (?max of ROSU) and 275 nm (?max of ASP), Second method i.e. Absorption ratio method was carried out at 242 nm (?max of ROSU) and 258 nm (isoabsorptive point of ROSU and ASP). Third method is Area under curve method, area under curve in the range of 237-247 nm (for ROSU) and 270-280 nm (for ASP) were selected for the analysis. The accuracy and precision of the methods were determined and validated. All the methods showed good reproducibility and recovery with % RSD less than 2. The proposed methods were found to be rapid, specific, precise, accurate and can be successfully applied for the routine analysis of ROSU and ASP in bulk and combined dosage form.
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